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desvenlafaxine will improve the stage or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment wanted with desvenlafaxine doses 7 consecutive days right away ah